TAKE-HOME MESSAGE This cross-sectional study aimed to evaluate the prevalence of gingival overgrowth and the differences among causative drugs in epileptic patients. A total of 162 patients were included, with the incidence of overgrowth among those taking a single drug (37%) being comparable with that among those taking multiple drugs (45%). Drugs in decreasing order of associated incidence of overgrowth were oxcarbazepine (71%), lamotrigine (61%), phenobarbital (53%), phenytoin (50%), valproic acid (44%), and carbamazepine (32%). Phenytoin and valproic acid have historically been known to cause gingival overgrowth in epileptic patients. The findings of this study remind us that multiple other drugs used in the management of epileptic patients have varying potential to cause gingival overgrowth, some with even higher potential than phenytoin and valproic acid. – Tapan N. Koticha, BDS, MDS Clinical Dentistry Written by ...
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