Effects of Bisphenol A Released From Composite Fillings on Reproductive Hormone Levels in Men

 

TAKE-HOME MESSAGE

  • Although pure BPA is not found in dental products, it may be present in an impure form or through degradation of BISDMA. A concern with BPA is potential endocrine disruption with estrogenic and anti-androgenic effects. This study took saliva and blood samples from 18 men before two composite restorations and 1, 3, and 5 weeks after the restorations were placed. BPA was found in serum and saliva, but it was determined that the released levels were below toxic doses, and no statistically significant correlation was found between BPA levels and hormone levels.

  • BPA from composite resin did not significantly alter serum hormone levels. This study provides further evidence of the safety of composite resins.
–  James Boynton, DDS, MS
OBJECTIVES

Composite resins are the most preferred filling material because of their excellent aesthetic qualities. However, a filling material should also be biocompatible as well as aesthetic. The aim of this study was to determine the serum and saliva bisphenol-A (BPA) levels and to examine the effects of serum BPA on reproductive hormone levels after healthy men were treated with composite fillings.

METHODS

Eighteen healthy males each received 2 composite restorations. Saliva and blood samples of subjects were collected before resin application and 1 day and 1, 3, and 5 weeks after the resin was applied. BPA amounts in samples were detected using high-performance liquid chromatography (HPLC). Serum gonadotropins, testosterone, sex hormone binding globulin, free androgen index, and oestrogen levels were measured with radioimmunological assay kits. Statistical analysis of data was made using Friedman, Wilcoxon signed ranks and Mann-Whitney U tests (α = 0.05).

RESULTS

The amount of BPA released from composite resins over time was not significantly elevated in either saliva or serum (P > 0.5). In addition, serum BPA levels were significantly higher than saliva BPA levels for both composites (P < .05), but saliva and serum BPA levels were not statistically different when comparing the 2 composites (P > .05).

CONCLUSIONS

BPA from composite resins used in this study did not significantly alter serum hormone levels.

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